Gold nanoparticles are suitable cores for building tunable iminosugar multivalency

Year: 2015

Authors: Matassini C., Marradi M., Cardona F., Parmeggiani C., Robina I., Moreno-Vargas A. J., Penadés S., Goti A.

Autors Affiliation: Dipartimento di Chimica “Ugo Schiff”, Università di Firenze, Via della Lastruccia 3-13, 50019 Sesto Fiorentino (FI), Italy;
CIC biomaGUNE, Biofunctional Nanomaterials Unit, Lab. GlycoNanoTechnology, San Sebastian Spain;
CIBER-BBN, San Sebastian Spain;
CNR – INO and LENS, Via N. Carrara 1, 50019 Sesto Fiorentino (FI), Italy;
Departamento de Quımica Org´anica, Facultad de Quımica, Universidad de Sevilla, Spain

Abstract: The first example of iminosugars multimerization based on gold nanoparticle cores was achieved by a straightforward synthetic strategy based on the use of simple glycosides of alpha-D-mannose or beta-Dglucose to modulate the density of biologically active pyrrolizidine and piperidine iminosugars at the gold surface. Exceptionally small and water dispersible gold colloids were obtained by self assembly of thiol ending sugar and novel iminosugar conjugates on the surface of in situ forming gold nanoparticles. The resulting nanostructures were characterized by different techniques. Preliminary screenings demonstrated that the novel nanosized architectures retain their bioactivity and make possible its modulation.

Journal/Review: RSC ADVANCES

Volume: 5 (116)      Pages from: 95817  to: 95822

More Information: We thank MIUR-Italy (PRIN 2010-2011, 2010L9SH3K 006), Ministero della Salute/Regione Toscana (Ricerca Finalizzata, RF-2011-02347694), MINECO (Spain, CT2011-27268) and the Ministerio de Economia y Competitividad (Spain, CTQ 201231247) for financial support. CM thanks Ente Cassa di Risparmio di Firenze (2013/0366) for a fellowship and the Basque Department of Economical Development and Competitiveness for cofinancing her PhD fellowship.
DOI: 10.1039/c5ra22152h

Citations: 16
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