Scientific Results

High-speed multifunctional scanning ion conductance
microscopy: Innovative strategies to study dynamic
cellular processes

Year: 2021

Authors: Tognoni E.

Autors Affiliation: INO (CNR) – Pisa

Abstract: The latest contributions of scanning ion conductance microscopy (SICM) to current research in life sciences are reviewed.
The continued efforts toward technical improvements in SICM
hardware and software resulted in development of new scanning
strategies and instrumental designs. Enhanced high-speed
mapping supported the capture of very fast cellular
processes at the nanoscale, such as secretory events or cilia
movements or the contraction cycle of a cardiomyocyte. The
noninvasive scanning capability allowed researchers to
monitor the response of individual live cells to chemical stimulations in real time. Access to new kinds of information that can be extracted from experimental data with the support of numerical simulations was demonstrated, thus extending
further SICM multifunction capability.

Journal/Review:

Volume: 28      Pages from: 100738  to: 100738

KeyWords: Scanning ion conductance microscopy, Nanopipette, Live cell imaging,
Nanoparticles, Nanosensor.
DOI: https://doi.org/10.1016/j.coelec.2021.100738

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