Preventive screening of colorectal cancer with a device based on chemoresistive sensors

Year: 2017

Authors: Zonta G., Anania G., Fabbri B., Gaiardo A., Gherardi S., Giberti A., Landini N., Malagu C., Scagliarini L., Guidi V.

Autors Affiliation: Univ Ferrara, Dept Phys & Earth Sci, Via Saragat 1-c, I-44122 Ferrara, Italy; MIST E R Scrl, Via P Gobetti 101, I-40129 Bologna, Italy; CNR, INO, Largo Enrico Fermi 6, I-50124 Florence, Italy; Univ Ferrara, Dept Morphol Surg & Expt Med, Via Luigi Borsari 46, I-44121 Ferrara, Italy;‎ Bruno Kessler Fdn, MNF, Via Sommarive 18, I-38123 Trento, Italy

Abstract: Colorectal cancer is one of the widely diffused tumors. Despite its high curable rate, if diagnosed in its polyp state, an efficient screening method is highly desirable for preventing and decreasing deaths. Tumor biomarkers, emitted by the peroxidation of the cell membrane, may alter the composition of feces. We developed an array of chemoresistive sensors (both metal oxides and sulfides) capable of distinguishing between real stool samples of healthy subjects and of patients with colorectal cancer at diverse degeneration stages. Preliminary clinical validation of real samples was carried out. Results have shown the selectivity of the sensor array towards tumor affected and healthy subject samples. A quadratic discriminant analysis was performed, with a classification error of about 5%. (C) 2016 Elsevier B.V. All rights reserved.


Volume: 238      Pages from: 1098  to: 1101

KeyWords: VOC; Colorectal cancer; Polyps; Chemoresistive sensors; Biomarkers; Screening
DOI: 10.1016/j.snb.2016.07.079

Citations: 11
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