Small-scale laser based electron accelerators for biology and medicine: a comparative study of the biological effectiveness

Year: 2013

Authors: Labate L., Andreassi M.G., Baffigi F., Basta G., Bizzarri R., Borghini A., Candiano G.C., Casarino C., Cresci M., Di Martino F., Fulgentini L., Ghetti F., Gilardi M.C., Giulietti A., Koster P., Lenci F., Levato T., Oishi Y., Russo G., Sgarbossa A., Traino C., Gizzi LA.

Autors Affiliation: ILIL, Istituto Nazionale di Ottica, Consiglio Nazionale delle Ricerche, Pisa, Italy; Istituto Nazionale di Fisica Nucleare, Sezione di Pisa e Laboratori Nazionali di Frascati, Italy; Istituto di Fisiologia Clinica, Consiglio Nazionale delle Ricerche, Pisa, Italy; Istituto di Biofisica, Consiglio Nazionale delle Ricerche, Pisa, Italy; Laboratorio di Tecnologie Oncologiche HSR-Giglio, Istituto di Bioimmagini e Fisiologia Molecolare, Consiglio Nazionale delle Ricerche, Cefalu, Italy; U.O. di Fisica Sanitaria, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Institute of Physics of the ASCR – ELI-Beams, Prague, Czech Republi; Dipartimento di Ignegneria Industriale, Universita di Tor Vergata, Roma, Italy

Abstract: Laser-driven electron accelerators based on the Laser Wakefield Acceleration process has entered a mature phase to be considered as alternative devices to conventional radiofrequency linear accelerators used in medical applications. Before entering the medical practice, however, deep studies of the radiobiological effects of such short bunches as the ones produced by laser-driven accelerators have to be performed. Here we report on the setup, characterization and first test of a small-scale laser accelerator for radiobiology experiments. A brief description of the experimental setup will be given at first, followed by an overview of the electron bunch characterization, in particular in terms of dose delivered to the samples. Finally, the first results from the irradiation of biological samples will be briefly discussed.

Journal/Review: PROCEEDINGS OF SPIE

Volume: 8779      Pages from: 87790O  to: 87790O

KeyWords: Laser WakeField Acceleration; Medical applications; Radiotherapy; NUCLEOCYTOPLASMIC TRANSPORT; BUBBLE REGIME
DOI: 10.1117/12.2019689

Citations: 7
data from “WEB OF SCIENCE” (of Thomson Reuters) are update at: 2024-11-10
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