Impact of electric spatially discordant alternans on cardiac magnetic field
Year: 2025
Authors: Nicoletti M., Crispino A., Loppini A., Gizzi A., Chiodo L., Cherubini C., Filippi S.
Autors Affiliation: Univ Campus Biomed Roma, Dept Engn, Via Alvaro del Portillo 21, I-00128 Rome, Italy; Ist Italiano Tecnol, Ctr Life Nano & Neuro Sci, Viale Regina Elena 291, I-00161 Rome, Lazio, Italy; Univ Campus Biomed Roma, Dept Med & Surg, Via Alvaro Portillo 21, I-00128 Rome, Lazio, Italy; CNR, Ist Nazl Ottica, Largo Enr Fermi, I-50125 Florence, Tuscany, Italy; Univ Campus Biomed Roma, Dept Sci & Technol Sustainable Dev & Hlth 1, Via Alvaro Portillo 21, I-00128 Rome, Lazio, Italy; ICRANet Int Ctr Relativist Astrophys Network, Piazza Repubbl 10, I-65122 Pescara, Italy.
Abstract: Spatially discordant alternans (SDA) play a crucial role in cardiac arrhythmogenesis by creating steep repolarization gradients facilitating conduction block and reentry. While traditionally studied using electrical indicators, this work provides an alternative perspective by characterizing SDA through their magnetic field signatures. Using a one-dimensional idealized cardiac fiber model, we demonstrate that magnetic-field measurements effectively detect SDA and temperature-dependent changes in cardiac action potentials, offering a noninvasive alternative to conventional electrophysiological metrics. Our results reveal that the spatial organization of SDA is mirrored in the distribution of the magnetic field, with SDA nodes clearly identifiable via spatial mapping. Notably, magnetic restitution curves exhibit a distinct pattern from action potential duration (APD)-based indicators, closely following the dynamics of the action potential upstroke. These findings establish the cardiac magnetic field as a powerful diagnostic tool for detecting SDA, opening alternative avenues for biomagnetic monitoring of arrhythmic risk.
Journal/Review: PHYSICAL REVIEW E
Volume: 112 (2) Pages from: 24405-1 to: 24405-12
More Information: This research was funded by the European Commission-EU under the HORIZON Research and Innovation Ac-tion MUQUABIS Grant Agreement No. 101070546, and by the European Union-NextGeneration EU, within PRIN 2022, PNRR M4C2, Project QUASAR 20225HYM8N [CUP C53D2300140 0008] . S.F. acknowledges the International Center for Relativistic Astrophysics Network-ICRANet. The authors wish to acknowledge the Italian National Group for Mathematical Physics, GNFM-INdAM.KeyWords: Coronary-artery-disease; Action-potentials; Mechanisms; Model; Fibrillation; Temperature; Hypothermia; ApexDOI: 10.1103/ys62-2n7g
