Experimental study of the mechanisms leading to the formation of glistenings in intraocular lenses by Raman spectroscopy

Anno: 2019

Autori: Rusciano G., Capaccio A., Pesce G., Sasso A.

Affiliazione autori: Univ Naples Federico II, Compl Univ MS Angelo, Dept Phys E Pancini, Via Cinthia, I-80126 Naples, Italy; Natl Inst Opt INO CNR, Comprensorio Olivetti Via Campi Flegrei 34, I-80078 Pozzuoli, NA, Italy.

Abstract: The phenomenon of glistenings, often appearing in intraocular lenses (IOLs) of patients after some time from the surgical operation, is potentially able to induce a poor quality of vision and, therefore, frustrate IOL implantation itself. In this paper, we combine optical microscopy with micro-Raman spectroscopy to get a deeper insight on the mechanism ruling, at microscopic scale, glistening formation. In particular, we have analyzed two types of IOLs, characterized by a different internal hydrophobicity but a similar polymer hydration coefficient. Raman imaging of single microvacuoles reveals that water creeps into the polymeric network, which traps water. Finally, applying the Principal Component Analysis (PCA) to Raman data, we provide information on the probable mechanism leading to water trapping in the two kinds of analyzed IOLs. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

Giornale/Rivista: BIOMEDICAL OPTICS EXPRESS

Volume: 10 (4)      Da Pagina: 1870  A: 1881

Parole chiavi: SOFT CONTACT-LENSES; POLY(METHYL METHACRYLATE); MOLECULAR-STRUCTURE; VISUAL FUNCTION; LIGHT SCATTER; WATER; SPECTRA; POLYMERIZATION; ABSORPTION; VIBRATIONS
DOI: 10.1364/BOE.10.001870

Citazioni: 8
dati da “WEB OF SCIENCE” (of Thomson Reuters) aggiornati al: 2024-09-08
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