Analysis of genomic patchiness of Haemophilus influenzae and Saccharomyces cerevisiae chromosomes

Anno: 1996

Autori: Lio P., Politi A., Ruffo S., Buiatti M.

Affiliazione autori: CRC Human Genetic Department, Princess Anne Hospital, University of Southampton, Southampton, U.K.; Istituto Nazionale di Ottica, Largo E. Fermi 6, 50125 Firenze, Italy; Dipartimento di Energetica, Università di Firenze, Via S. Marta 3, 50139 Firenze, Italy; Dipartimento di Biologia Animale e Genetica, Università di Firenze, Via Romana 17, 50125 Firenze, Italy; INFN e INFM, Firenze, Italy

Abstract: We have analysed some aspects of the primary structure of the chromosome of the prokaryote Haemophilus influenzae and of the eukaryote Saccharomyces cerevisiae that share the same G + C content. In particular, we have investigated genomic patchiness over the gene size level (10 Kb) and that patchiness due to long homogeneous tracts. Long polypurine and polypyrmidine tracts that are largely over-represented in S. cerevisiae chromosomes and under-represented in H. influenzae, are responsible for a large fraction of long correlation signals. Generating mechanisms of long homogeneous tracts are DNA replication slippage and duplication events that appear to be linked processes driving chromosome primary structure evolution. (C) 1996 Academic Press Limited

Giornale/Rivista: JOURNAL OF THEORETICAL BIOLOGY

Volume: 183 (4)      Da Pagina: 455  A: 469

Maggiori informazioni: This work is part of the activity sponsored by INFM Forum Pisa and Firenze
Parole chiavi: Stepwise Mutation Model; Meiotic Recombination; Nucleotide-sequences; Codon Reiteration; Polypurine Tract; Universal Rule; Dna-sequence; Evolution; Organization; Replication
DOI: 10.1006/jtbi.1996.0235

Citazioni: 11
dati da “WEB OF SCIENCE” (of Thomson Reuters) aggiornati al: 2025-05-18
Riferimenti tratti da Isi Web of Knowledge: (solo abbonati)
Link per visualizzare la scheda su IsiWeb: Clicca qui
Link per visualizzare la citazioni su IsiWeb: Clicca qui