Collagen ultrastructural symmetry and its malignant alterations in human breast cancer revealed by polarization-resolved second-harmonic generation microscopy

Anno: 2020

Autori: Mercatelli R., Triulzi T., Pavone FS., Orlandi R., Cicchi R.

Affiliazione autori: Natl Res Council CNR INO, Natl Inst Opt, Via Nello Carrara 1, I-50019 Sesto Fiorentino, Italy; Aerosp Tecnol Srl, Rapolano Terme, SI, Italy; Fdn IRCCS Ist Nazl Tumori, Milan, Italy; Univ Florence, Dept Phys, Sesto Fiorentino, Italy; European Lab Nonlinear Spect LENS, Sesto Fiorentino, Italy.

Abstract: Several specific alterations of the extracellular matrix can be considered a distinctive hallmark of cancer. In particular, a different morphology of the collagen scaffold is frequently found within the peritumoural environment. In this study, we report about a significant difference in the ultrastructural organization of collagen at the supramolecular
level between the perilesional scaffold and the tumour area in human breast carcinoma samples. In particular, we demonstrated that polarizationresolved second-harmonic generation (P-SHG) microscopy is able to link the altered collagen architecture at the ultrastructural level found in perilesional tissue with a different organization of collagen fibrils at the molecular level.

Giornale/Rivista: JOURNAL OF BIOPHOTONICS

Volume: 13 (8)      Da Pagina: e202000159  A: e202000159

Maggiori informazioni: Horizon 2020 Framework Programme, Grant/Award Number: 654148 & 732111; Ministero della Salute, Grant/Award Number: GR-2011-02349626; Seventh Framework Programme, Grant/Award Number: EU FP7 BiophotonicsPlus – LITE; Associazione Italiana per la Ricerca sul Cancro, Grant/Award Number: 12162; Horizon 2020; Ministry of Health; Tuscany Region
Parole chiavi: breast cancer, collagen, polarization, SHG microscopy
DOI: 10.1002/jbio.202000159

Citazioni: 23
dati da “WEB OF SCIENCE” (of Thomson Reuters) aggiornati al: 2025-05-18
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