Analysis of genomic patchiness of Haemophilus influenzae and Saccharomyces cerevisiae chromosomes
Anno: 1996
Autori: Lio P., Politi A., Ruffo S., Buiatti M.
Affiliazione autori: CRC Human Genetic Department, Princess Anne Hospital, University of Southampton, Southampton, U.K.; Istituto Nazionale di Ottica, Largo E. Fermi 6, 50125 Firenze, Italy; Dipartimento di Energetica, Università di Firenze, Via S. Marta 3, 50139 Firenze, Italy; Dipartimento di Biologia Animale e Genetica, Università di Firenze, Via Romana 17, 50125 Firenze, Italy; INFN e INFM, Firenze, Italy
Abstract: We have analysed some aspects of the primary structure of the chromosome of the prokaryote Haemophilus influenzae and of the eukaryote Saccharomyces cerevisiae that share the same G + C content. In particular, we have investigated genomic patchiness over the gene size level (10 Kb) and that patchiness due to long homogeneous tracts. Long polypurine and polypyrmidine tracts that are largely over-represented in S. cerevisiae chromosomes and under-represented in H. influenzae, are responsible for a large fraction of long correlation signals. Generating mechanisms of long homogeneous tracts are DNA replication slippage and duplication events that appear to be linked processes driving chromosome primary structure evolution. (C) 1996 Academic Press Limited
Giornale/Rivista: JOURNAL OF THEORETICAL BIOLOGY
Volume: 183 (4) Da Pagina: 455 A: 469
Parole chiavi: STEPWISE MUTATION MODEL; MEIOTIC RECOMBINATION; NUCLEOTIDE-SEQUENCES; CODON REITERATION; POLYPURINE TRACTDOI: 10.1006/jtbi.1996.0235Citazioni: 11dati da “WEB OF SCIENCE” (of Thomson Reuters) aggiornati al: 2024-05-12Riferimenti tratti da Isi Web of Knowledge: (solo abbonati) Link per visualizzare la scheda su IsiWeb: Clicca quiLink per visualizzare la citazioni su IsiWeb: Clicca qui